Efecto vasodilatador de factor de crecimiento vascular endotelial (VEGF) en arterias de tumores colorrectales

Efecto vasodilatador de factor de crecimiento vascular endotelial (VEGF) en arterias de tumores colorrectales

Vasodilator effect of vascular endothelial growth factor (VEGF) on arteries from colorectal tumors

Oscar García Villar*, Eduardo Ferrero Herrero*, Miriam Granado García**, Ángel Luis García Villalón**

* Servicio de Cirugía General, Aparato Digestivo y Trasplante de Órganos Abdominales. Hospital Universitario “12 de Octubre”, Universidad Complutense, Avenida de Córdoba, s/n, 28041 Madrid, España.
** Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, Arzobispo Morcillo 2, 28029 Madrid, España.

DOI: 10.14679/2328

Resumen: 

Para estudiar si el efecto del factor de crecimiento vascular endotelial (VEGF) está alterado en las arterias tumorales, se obtuvieron arterias mesentéricas irrigando el tumor y arterias mesentéricas de una región alejada del mismo (controles) de 4 pacientes intervenidos quirúrgicamente por cáncer colorrectal, y se montaron en una preparación para el registro de la contracción isométrica en un baño de órganos. La depolarización del músculo liso vascular mediante una concentración elevada de potasio (100 mM) produjo contracción que fue menor en las arterias del tumor que en las controles. En las arterias contraídas previamente con el análogo del tromoboxano U46618, el VEGF (10-8-10-9 M) produjo relajación que fue similar en las arterias del tumor que en las controles. Estos resultados indican que en las arterias de tumores colorrectales la capacidad vasoconstrictora del músculo liso está reducida pero el efecto vasodilatador del VEGF está preservado, lo que puede contribuir a mantener el flujo sanguíneo al tumor durante su crecimiento.
Palabras clave: arterias, músculo liso, tumor colorrectal.

Abstract: 

To study whether the effect of the vascular endothelial growth factor is altered in tumoral arteries, arteries mesenteric arteries supplying blood flow to colorectal tumors, and mesenteric arteries far from said tumors were obtained from 4 patients undergoing colectomy, and these arteries were prepared for isometric tension recording in an organ bath. Depolarization of the vascular smooth muscle with a high concentration of potassium (100 mM) produced contraction which was similar in the arteries from the tumor and in control arteries. After precontration with the thromboxane analog U46619, VEGF (10-8-10-9 M) produced relaxation which was similar in the arteries from the tumor and in control arteries. These results indicate than in the arteries from colorectal tumors the vasoconstrictor function of the smooth muscle is impaired, but the vasodilator effect of VEGF is preserved, which may contribute to maintaining the blood flow to the tumor during its growth.
Key words: arterias, músculo liso, tumor colorrectal.

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