Modificación a la escisión mesorrectal total transanal

  • Título abreviado Modificación a la escisión mesorrectal total transanal
  • Abbreviated title Modified transanal total mesorectal excision
  • Autores M. Labalde Martínez
    C. Nevado García
    P. Peláez Torres
    S. Lorenzo Mañas
    D. Alías Jiménez
    A. Vivas López
    F.J. García Borda
    E. Ferrero Herrero
  • Categoría Cirugía colorrectal
  • Fecha de recepción 06-09-2024
  • ISSN 3020-2655
  • Fecha de aceptación 25-09-2024
  • Páginas 11
  • Número 2:9

Modificación a la escisión mesorrectal total transanal para el tratamiento del cáncer de recto bajo y medio

Modified transanal total mesorectal excision for low rectal cancer

M. Labalde Martínez*, C. Nevado García*, P. Peláez Torres*, S. Lorenzo Mañas*, D. Alías Jiménez*, A. Vivas López*, F.J. García Borda*, E. Ferrero Herrero*

* Servicio de Cirugía General, Aparato Digestivo y Trasplante de
     Órganos Abdominales. Unidad de Cirugía Colorrectal.
     Hospital Universitario 12 de Octubre. Madrid (España).

DOI: https://doi.org/10.14679/3506
Resumen:

Introducción: Se proponen modificaciones a la escisión mesorrectal total transanal que consisten fundamentalmente en realizar la escisión mesorrectal por vía transanal sólo de los planos más distales. El objetivo es describir los resultados del TaTME modificado. Material y métodos: 15 pacientes (8 varones y 7 mujeres) con una edad de 68 (48-76) años con cáncer de recto medio-bajo son sometidos a TaTME modificado. Se coloca la plataforma Gel-point transanal para la creación del neumorrecto estable. Bajo visualización directa del tumor se cierra el recto con una sutura en bolsa de tabaco. Se procede a la rectotomía y se inicia la escisión mesorrectal total de los planos más distales hasta liberar y movilizar sólo el mesorrecto distal circunferencialmente. Bajo neumoperitoneo se procede a la escisión mesorrectal total desde proximal a distal hasta encontrarse con el plano más distal trabajado en la fase transanal. Se extrae la pieza por el ano, se secciona el recto y se cierra el muñón rectal con una segunda bolsa de tabaco. La anastomosis colorrectal con una endograpadora circular evitando la técnica del doble grapado. Resultados: 13 casos eran cT3 y 5 de N+. Recibieron neoadyuvancia 11 pacientes. En todos los casos la escisión mesorrectal total fue completa y los márgenes distal y radial circunferencial estaban libres de enfermedad. No se registraron complicaciones postoperatorias ni fístulas. La estancia hospitalaria fue de 7 (6-8) días. No hubo reintervenciones y un paciente reingresó por suboclusión intestinal. Conclusión: Las modificaciones descritas en la técnica de TaTME son factibles y seguras.
Palabras claves: escisión mesorrectal total transanal, cáncer de recto, TATME

Abstract:

Introduction. We propose modifications to transanal total mesorectal excision consisting on performing the total mesorectal excision by transanal approach only of the most distal planes of the pelvis. The aim is to describe the results of the modified TaTME. Material and methods. 15 patients (8 males and 7 females) with a mean age of 68 (48-76) years old with mid-low rectal cancer underwent modified to TaTME. Gel-point transanal paltform was used to create a stable pneumorrectum. Under direct visualization of the tumour the rectum is closed using a purse-string suture. Rectotomy was performed and the total mesorectal excision was initiated from the most distal plane to mobilize and realease circumferentially the distal mesorectum. Under neumoperitoneum total mesorectal excision was performed from proximal to distal plane and finally the rendez-vous point was found. The piece was extracted through the anus, the rectum was sectionated and the rectal stump was closed with a second purse-string suture. Results. 13 cases were cT3 and 5 N+. 11 patients received neadjuvant therapy. The rate of complete total mesorectal excision, rate of free distal margin and circumferential radial margin were 100 %, 100 % and 100 % respectively. There were not postoperative complications and anastomotic leaks. There were not reinterventions and one patient was readmitted because of intestinal suboclusion. Conclusion. The modifications to transanal total mesorectal excision described in this study were feasible and secure.
Keywords: trananal toral mesorectal excision, carcinoma of rectum, TATME

Bibliografía
      1. Labalde Martínez, M., García Borda, F.J., Alcalde Escribano, Nevado García, C., Rubio González E., García Villar O., Peláez Torres P., Cruz Vigo F., Ferrero Herrero E. Transanal total mesorectal excision and adverse conditions for laparoscopic total mesorectal excision. Eur Surg 52, 88–95 (2020). https://doi.org/10.1007/s10353-019-00626-y
      2. Lacy AM, Tasende MM, Delgado S, Fernandez-Hevia M, Jimenez M, De Lacy B, Castells A, Bravo R, Wexner SD, Heald RJ. Transanal Total Mesorectal Excision for Rectal Cancer: Outcomes after 140 Patients. J Am Coll Surg. 2015 Aug;221(2):415-23. doi: 10.1016/j.jamcollsurg.2015.03.046. Epub 2015 Mar 30. PMID: 26206640.
      3. Labalde Martínez M, García Borda J, Nevado García C, Alcalde Escribano J, de la Cruz Vigo F, Ferrero Herrero E. Escisión mesorrectal total transanal (tatme): aspectos prácticos de la técnica quirúrgica. Rev Esp Invest Quirur 2019; 22(4):147-155.
      4. de Lacy FB, van Laarhoven JJEM, Pena R, Arroyave MC, Bravo R, Cuatrecasas M, Lacy AM. Transanal total mesorectal excision: pathological results of 186 patients with mid and low rectal cancer. Surg Endosc. 2018 May;32(5):2442-2447. doi: 10.1007/s00464-017-5944-8. Epub 2017 Nov 3. PMID: 29101570.
      5. Penna M, Hompes R, Arnold S, Wynn G, Austin R, Warusavitarne J, Moran B, Hanna GB, Mortensen NJ, Tekkis PP; TaTME Registry Collaborative. Transanal Total Mesorectal Excision: International Registry Results of the First 720 Cases. Ann Surg. 2017 Jul;266(1):111-117. doi: 10.1097/SLA.0000000000001948. PMID: 27735827.
      6. Penna M, Hompes R, Arnold S, Wynn G, Austin R, Warusavitarne J, Moran B, Hanna GB, Mortensen NJ, Tekkis PP; International TaTME Registry Collaborative. Incidence and Risk Factors for Anastomotic Failure in 1594 Patients Treated by Transanal Total Mesorectal Excision: Results From the International TaTME Registry. Ann Surg. 2019 Apr;269(4):700-711. doi: 10.1097/SLA.0000000000002653. PMID: 29315090.
      7. Roodbeen SX, de Lacy FB, van Dieren S, Penna M, Ris F, Moran B, Tekkis P, Bemelman WA, Hompes R; International TaTME Registry Collaborative. Predictive Factors and Risk Model for Positive Circumferential Resection Margin Rate After Transanal Total Mesorectal Excision in 2653 Patients With Rectal Cancer. Ann Surg. 2019 Nov;270(5):884-891. doi: 10.1097/SLA.0000000000003516. PMID: 31634183.
      8. Wasmuth HH, Faerden AE, Myklebust TÅ, Pfeffer F, Norderval S, Riis R, Olsen OC, Lambrecht JR, Kørner H, Larsen SG; Norwegian TaTME Collaborative Group, on behalf of the Norwegian Colorectal Cancer Group; Forsmo HM, Baekkelund O, Lavik S, Knapp JC, Sjo O, Rashid G. Transanal total mesorectal excision for rectal cancer has been suspended in Norway. Br J Surg. 2020 Jan;107(1):121-130. doi: 10.1002/bjs.11459. Epub 2019 Dec 5. PMID: 31802481.
      9. Jessup J, Benson A, Chen V: Colon and rectum. In: Amin MB, Edge SB, Greene FL, et al., eds.: AJCC Cancer Staging Manual. 8th ed. New York, NY: Springer, 2017, pp 251-74.
      10. Glynne-Jones R, Wyrwicz L, Tiret E, Brown G, Rödel C, Cervantes A, Arnold D; ESMO Guidelines Committee. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2017 Jul 1;28(suppl_4):iv22-iv40. doi: 10.1093/annonc/mdx224. Erratum in: Ann Oncol. 2018 Oct 1;29(Suppl 4):iv263. doi: 10.1093/annonc/mdy161. PMID: 28881920.
      11. Nagtegaal ID, van de Velde CJ, van der Worp E, Kapiteijn E, Quirke P, van Krieken JH; Cooperative Clinical Investigators of the Dutch Colorectal Cancer Group. Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologist in quality control. J Clin Oncol. 2002 Apr 1;20(7):1729-34. doi: 10.1200/JCO.2002.07.010. PMID: 11919228.
      12. Ryan R, Gibbons D, Hyland JM, Treanor D, White A, Mulcahy HE, O’Donoghue DP, Moriarty M, Fennelly D, Sheahan K. Pathological response following long-course neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Histopathology. 2005 Aug;47(2):141-6. doi: 10.1111/j.1365-2559.2005.02176.x. PMID: 16045774.
      13. Ma B, Gao P, Song Y, Zhang C, Zhang C, Wang L, Liu H, Wang Z. Transanal total mesorectal excision (taTME) for rectal cancer: a systematic review and meta-analysis of oncological and perioperative outcomes compared with laparoscopic total mesorectal excision. BMC Cancer. 2016 Jul 4;16:380. doi: 10.1186/s12885-016-2428-5. PMID: 27377924; PMCID: PMC4932707.
      14. Aubert M, Mege D, Panis Y. Total mesorectal excision for low and middle rectal cancer: laparoscopic versus transanal approach-a meta-analysis. Surg Endosc. 2020 Sep;34(9):3908-3919. doi: 10.1007/s00464-019-07160-8. Epub 2019 Oct 15. PMID: 31617090.
      15. Penna M, Hompes R, Arnold S, Wynn G, Austin R, Warusavitarne J, Moran B, Hanna GB, Mortensen NJ, Tekkis PP; International TaTME Registry Collaborative. Incidence and Risk Factors for Anastomotic Failure in 1594 Patients Treated by Transanal Total Mesorectal Excision: Results From the International TaTME Registry. Ann Surg. 2019 Apr;269(4):700-711. doi: 10.1097/SLA.0000000000002653. PMID: 29315090.
      16. Penna M, Hompes R, Arnold S, Wynn G, Austin R, Warusavitarne J, Moran B, Hanna GB, Mortensen NJ, Tekkis PP; TaTME Registry Collaborative. Transanal Total Mesorectal Excision: International Registry Results of the First 720 Cases. Ann Surg. 2017 Jul;266(1):111-117. doi: 10.1097/SLA.0000000000001948. PMID: 27735827.
      17. Roodbeen SX, de Lacy FB, van Dieren S, Penna M, Ris F, Moran B, Tekkis P, Bemelman WA, Hompes R; International TaTME Registry Collaborative. Predictive Factors and Risk Model for Positive Circumferential Resection Margin Rate After Transanal Total Mesorectal Excision in 2653 Patients With Rectal Cancer. Ann Surg. 2019 Nov;270(5):884-891. doi: 10.1097/SLA.0000000000003516. PMID: 31634183.
      18. Hol JC, van Oostendorp SE, Tuynman JB, Sietses C. Long-term oncological results after transanal total mesorectal excision for rectal carcinoma. Tech Coloproctol. 2019 Sep;23(9):903-911. doi: 10.1007/s10151-019-02094-8. Epub 2019 Oct 10. PMID: 31599385; PMCID: PMC6791915.
      19. Li Z, Liu H, Luo S, Hou Y, Zhou Y, Zheng X, Zhang X, Huang L, Zeng Z, Kang L. Long-term oncological outcomes of transanal versus laparoscopic total mesorectal excision for mid-low rectal cancer: a retrospective analysis of 2502 patients. Int J Surg. 2024 Mar 1;110(3):1611-1619. doi: 10.1097/JS9.0000000000000992. PMID: 38091943; PMCID: PMC10942237.
      20. Moon JY, Lee MR, Ha GW. Long-term oncologic outcomes of transanal TME compared with transabdominal TME for rectal cancer: a systematic review and meta-analysis. Surg Endosc. 2022 May;36(5):3122-3135. doi: 10.1007/s00464-021-08615-7. Epub 2021 Jun 24. PMID: 34169371; PMCID: PMC9001551.
      21. Bjoern MX, Nielsen S, Perdawood SK. Quality of Life After Surgery for Rectal Cancer: a Comparison of Functional Outcomes After Transanal and Laparoscopic Approaches. J Gastrointest Surg. 2019 Aug;23(8):1623-1630. doi: 10.1007/s11605-018-4057-6. Epub 2019 Jan 2. PMID: 30603861.
      22. Rubinkiewicz M, Zarzycki P, Witowski J, Pisarska M, Gajewska N, Torbicz G, Nowakowski M, Major P, Budzyński A, Pędziwiatr M. Functional outcomes after resections for low rectal tumors: comparison of Transanal with laparoscopic Total Mesorectal excision. BMC Surg. 2019 Jul 5;19(1):79. doi: 10.1186/s12893-019-0550-4. PMID: 31277628; PMCID: PMC6612175.
      23. Labalde Martínez M, Vivas Lopez A, Ocaña Jimenez J, Nevado García C, García Villar O, Rubio Gonzalez E, García Borda FJ, Cruz Vigo F, Ferrero Herrero E. Quality Indicators of Transanal Total Mesorectal Excision (TaTME) for Rectal Cancer. Journal of Coloproctology 2021;41:411-8. https://doi.org/10.1055/s-0041-1736640.
      24. Labalde Martínez M, Nevado García C, García Borda FJ, Vivas Lopez A, García Villar O, Rubio Gonzalez E, Peláez Torres P, Ferrero Herrero E. Long-term outcomes of transanal total mesorectal excision for rectal cancer: what could we do to improve them? Minerva Surg. 2022 Dec;77(6):564-572. doi: 10.23736/S2724-5691.22.09463-1. PMID: 36409038.
      25. Koedam TWA, Veltcamp Helbach M, van de Ven PM, Kruyt PM, van Heek NT, Bonjer HJ, Tuynman JB, Sietses C. Transanal total mesorectal excision for rectal cancer: evaluation of the learning curve. Tech Coloproctol. 2018 Apr;22(4):279-287. doi: 10.1007/s10151-018-1771-8. Epub 2018 Mar 22. PMID: 29569099.
      26. Lee L, Kelly J, Nassif GJ, deBeche-Adams TC, Albert MR, Monson JRT. Defining the learning curve for transanal total mesorectal excision for rectal adenocarcinoma. Surg Endosc. 2020 Apr;34(4):1534-1542. doi: 10.1007/s00464-018-6360-4. Epub 2018 Jul 11. PMID: 29998391.
      27. Zmora O, Gervaz P, Wexner SD. Trocar site recurrence in laparoscopic surgery for colorectal cancer. Surg Endosc. 2001 Aug;15(8):788-93. doi: 10.1007/s004640080151. Epub 2001 Jun 12. PMID: 11443452.
      28. Verseveld M, Barendse RM, Gosselink MP, Verhoef C, de Graaf EJ, Doornebosch PG. Transanal minimally invasive surgery: impact on quality of life and functional outcome. Surg Endosc. 2016 Mar;30(3):1184-7. doi: 10.1007/s00464-015-4326-3. Epub 2015 Jul 3. PMID: 26139488; PMCID: PMC4757623.
      29. Foppa C, Carrano FM, Spinelli A. Functional Outcomes after Transanal Surgery. Clin Colon Rectal Surg. 2022 Feb 28;35(2):146-154. doi: 10.1055/s-0041-1742116. PMID: 35237111; PMCID: PMC8885153.
      30. Spinelli A, Foppa C, Carvello M, Sacchi M, De Lucia F, Clerico G, Carrano FM, Maroli A, Montorsi M, Heald RJ. Transanal Transection and Single-Stapled Anastomosis (TTSS): A comparison of anastomotic leak rates with the double-stapled technique and with transanal total mesorectal excision (TaTME) for rectal cancer. Eur J Surg Oncol. 2021 Dec;47(12):3123-3129. doi: 10.1016/j.ejso.2021.08.002. Epub 2021 Aug 6. PMID: 34384655.
      31. Harji D, Fernandez B, Boissieras L, Celerier B, Rullier E, Denost Q. IDEAL Stage 2a/b prospective cohort study of transanal transection and single-stapled anastomosis for rectal cancer. Colorectal Dis. 2023 Dec;25(12):2346-2353. doi: 10.1111/codi.16789. Epub 2023 Nov 2. PMID: 37919463.
      32. Flynn J, Larach JT, Kong JCH, Waters PS, Warrier SK, Heriot A. The learning curve in robotic colorectal surgery compared with laparoscopic colorectal surgery: a systematic review. Colorectal Dis. 2021 Nov;23(11):2806-2820. doi: 10.1111/codi.15843. Epub 2021 Aug 15. PMID: 34318575.
      33. Jayne D, Pigazzi A, Marshall H, Croft J, Corrigan N, Copeland J, Quirke P, West N, Rautio T, Thomassen N, Tilney H, Gudgeon M, Bianchi PP, Edlin R, Hulme C, Brown J. Effect of Robotic-Assisted vs Conventional Laparoscopic Surgery on Risk of Conversion to Open Laparotomy Among Patients Undergoing Resection for Rectal Cancer: The ROLARR Randomized Clinical Trial. JAMA. 2017 Oct 24;318(16):1569-1580. doi: 10.1001/jama.2017.7219. PMID: 29067426; PMCID: PMC5818805.
      34. Feng Q, Yuan W, Li T, Tang B, Jia B, Zhou Y, Zhang W, Zhao R, Zhang C, Cheng L, Zhang X, Liang F, He G, Wei Y, Xu J; REAL Study Group. Robotic versus laparoscopic surgery for middle and low rectal cancer (REAL): short-term outcomes of a multicentre randomised controlled trial. Lancet Gastroenterol Hepatol. 2022 Nov;7(11):991-1004. doi: 10.1016/S2468-1253(22)00248-5. Epub 2022 Sep 8. PMID: 36087608.
      35. Sebastián-Tomás JC, Martínez-Pérez A, Martínez-López E, de’Angelis N, Gómez Ruiz M, García-Granero E. Robotic transanal total mesorectal excision: Is the future now? World J Gastrointest Surg. 2021 Aug 27;13(8):834-847. doi: 10.4240/wjgs.v13.i8.834. PMID: 34512907; PMCID: PMC8394387.